We went through all this with Sarmanos at the beginning of this, but it never got linked in this topic for others, so this is just a recap if someone else needs it. Pretty sure you've already figured all this out, since the results wouldn't have changed if you didn't.
Setting the cpu affinity in the toolset uses a different setting and ini file than the game:
Re: Today hates me I swear
All the other tips suggested for anything so far (the consolidated version post):
Modifying nwn.ini and nwnplayer.ini
* That topic is always in my sig now, and hopefully will be updated if we ever figure this one out
More or better written descriptions of many fixes on the
PC Gaming Wiki.
Now for some new ideas. The old Bioware forum has a topic specifically about at least some of these issues here:
Slow Toolset or it just works this way?
* That is a link using the internet archive, since the forums are shut down now, so hopefully they got a real good backup before it went poof. It looks like it did a lot of the more recent ones with French as the language for the overall gui, so you may have to suffer through that if the English or other languages weren't done.
In that topic, a fix is posted a ways down for NWNTX by virusman and some slowness, but doesn't sound perfect (don't let his name scare you. He does amazing stuff for NWN). Give it a try though. Seems to be some sort of caching issue with a lot of files, which isn't surprising. This doesn't seem to be specific to NWNTX, but I doubt the old toolset will see any new updates. Some people have tweaked the gui and other things for bigger screens*, but they all work with NWNTX as well.
* NWN Toolset - Modification (NWNX Forum) is an old one I used for years, though the link to the file is dead. Backup copy here.
Something new I found today that I still haven't tried was posted on another board, but you'll need to login to get the details (or use Google's cache... nasty bots): Re: New Neverwinter Aurora Toolset Improvements
I'll add them to the tips and tricks stuff after I've had some time to test the last one, but you can use NWNTX Loader.exe with them same as always (remember to reset the compatibility mode on them, and maybe run as admin). BACKUP YOUR ORIGINAL nwtoolset.exe!!!
As far as not being able to use compatibility mode, are you changing the settings on the NWNTX Loader.exe as well as the nwtoolset.exe? Pretty much everything will need to run as admin and use XP-SP3 mode.
If there is some way to exclude the modules/temp0 folder from various file scanning as well, it might help (antivirus etc.). That's the toolset's working folder and all the module content being used will get edited in there. It also has to grab files from the haks, bifs (data folder), texturepacks, override, portraits... so many folders, but if those didn't slow you down before, I don't see it making a big difference with this now. I hate ever recommending turning off the stuff that keeps viruses away just for more speed, but in this case, it might be worth a quick test.
There is also one more things I'd suggest if any of you are just using a copy of your nwn folder on a new system (or different location). The game itself is happy running without setting up the registry settings for its location, but it appears the
toolset does need them for at least the copy/paste stuff, to keep the clipboard happy with other apps. I doubt this is the cause of your issues, but you never know. Running nwconfig.exe may set them up for you without manually editing your registry, but if not, do back it up first. Also note the different locations between 32 and 64 bit versions there.
I'm like tizmo, and stopped using the toolset script editor long ago (function searching/prototype preview was useful, but oh well). Usually I'll use np++ witth a lot of tweaks for nwn scripting, but it is the same idea as sublime 3. Having all the resources extracted in a set of folders makes script searching quite nice, and the new compiler works fine externally (like the old PrC one), rather than having to compile them in the toolset. Unfortunately that is just one small part of what the toolset is used for.
I'll keep digging for more, but with so many old resources gone, like the Bio-boards, searching is not as easy with regular Google and other methods, though the
new vault forums are looking pretty good now (with a back up of the Bio-ones).
The Internet Archive is a great thing, but most forum searches break with it. Also, since this problem mainly seems to affect those working with pretty insane content counts (Avlis uses so many files), there aren't as many having issues with it.